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Biotechnology Information
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Biotechnology Information
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Image Search Results
Journal: Nature
Article Title: A comparative encyclopedia of DNA elements in the mouse genome
doi: 10.1038/nature13992
Figure Lengend Snippet: a , Principal component analysis (PCA) was performed for RNA-seq data for 10 human and mouse matching tissues. The expression values are normalized across the entire data set. Solid squares denote human tissues. Open squares denote mouse tissues. Each category of tissue is represented by a different colour. b , Gene expression variance decomposition (see Methods) estimates the relative contribution of tissue and species to the observed variance in gene expression for each orthologous human–mouse gene pair. Green dots indicate genes with higher between-tissue contribution and red dots genes with higher between-species contributions. c , Neighbourhood analysis of conserved co-expression (NACC) in human and mouse samples. The distribution of NACC scores for each gene is shown. d , A scatter plot shows the average of NACC score over the set of genes in each functional gene ontology category. Highlighted are those biological processes that tend to be more conserved between human and mouse and those processes that have been less conserved (see for list of genes).
Article Snippet: Extended Data Figure 1 Clustering analysis of human and mouse tissue samples. a ,
Techniques: RNA Sequencing Assay, Expressing, Functional Assay
Journal: Nature
Article Title: A comparative encyclopedia of DNA elements in the mouse genome
doi: 10.1038/nature13992
Figure Lengend Snippet: a , RNA-seq data from Ilumina Body Map (adipose, adrenal, brain, colon, heart, kidney, liver, lung, ovary and testis) were analysed together with that from the matched mouse samples using clustering analysis. Genes with high variance across tissues were used, resulting in cell samples clustering by tissues, not by species. b , Clustering employing genes with high variance between species shows clustering by species instead of tissues. c , Principal Component Analysis (PCA) was performed for RNA-seq data for 10 human and mouse matching tissues. The expression values are normalized within each species and we observed the clustering of samples by tissue types.
Article Snippet: Extended Data Figure 1 Clustering analysis of human and mouse tissue samples. a ,
Techniques: RNA Sequencing Assay, Expressing